lol.. i thought the title says, Night shots without tripod? so why are there so many people saying about use tripod? i believe he ask whats happens if u went out and forgot to bring a tripod..
Well, i always take night shots without tripod.. And the thing about ISO is that the higher u set it, the more noise u get.. So i always set at ISO 1200, then bump up slowly, changing the shutter speed as i go.. changing the white balance and flash exposure compensation also helps.. Always try to find the nearest support.. be it railings, dustbins, chairs, tables.. whatever u can find and is stable, use it..