I've found that certain programs don't work on Safari. Some animations don't work, page dimensions are weird, and it hangs on me! It doesn't hang quite as much as IE, though. Firefox is smoooooooooooth. :thumbsup:
There is no anti-phishing technology. The browser itself isn't really any more insecure than the others, though. However, even Internet Exploder 7 has some support for anti-phishing technology, though it's the least secure of browsers consistently.
I'd rather use Firefox, but Safari isn't a bad choice either. You just have to be more aware of what you're doing.