PhotoAcute can be used to remove high ISO noise and yet improve details at the same time. This is not possible with the usual noise reduction software as they usually cause details to be blurred as a result.
The example here is obtained by shooting the Olympus E3 at ISO 3200. Everybody knows that Olympus' high ISO performance is not as good as other brands of DSLRs and users normally would not shoot at ISO 3200 unless their life depended on it.
This is ISO 3200 image before PhotoAcute is applied.
This is the resulting image when PhotoAcute is used to remove the high ISO noise.
Not very obvious when comparing the down-sized images?
This is the 100% crop of the original image before PhotoAcute
This is the 100% crop after PhotoAcute is applied
Check out the difference in the noise level and especially check out difference in clarity in the fine text.
It is best to have as little movement of the subject as possible but if there are movements, then the software takes the moving objects from the first frame while working its magic on the rest of the stationary parts of the images so that it would not result in blurred objects in the merged image.