If you've noticed in your photo, part of the first tower is being obscured by the museum. The rythem of odds(3) is being disrupted.
This gets worse as you move along the bay towards the Flyer's direction because the museum gets even closer to you and obscure more of the towers. Then there is an issue with compositional balance. Don't you find your photo left heavy? The museum and towers occupy so much space on the left where there is virtually nothing on the right(above the convention centre). These are reasons why I've never taken a shot of the MBS from the Esplanade side ever since the museum took shape.